Our Group

Prof. Pasi Virta, Group Leader

Pasi Virta became professor of Organic Chemistry at Department of Chemistry, University of Turku 1.9.2016.

Main interests: Synthesis of biomolecular conjugates (oligonucleotides, carbohydrates and peptides), Transitions of higher order secondary structures of oligonucleotides, Biodistribution studies of oligomeric biomolecules, DNA-templated ligation, DNA-templated glycosylation, Glycosylation in aquosus media, Chemical modification of rare nucleosides.

 

 

 

Asst. Prof. Tuomas Lönnberg

Tuomas Lönnberg was appointed Assistant Professor of Organic Chemistry at the Department of Chemistry, University of Turku in Oct 2016.

Main research interests: Synthesis and properties of oligonucleotides incorporating organometallic  nucleobase surrogates, Metal mediated base pairing, Mechanisms of biologically relevant phosphate-transfer reactions.

 

 

 

 

Dr. Satu Mikkola, Senior Lecturer

Satu Mikkola has been working as a senior lecturer in organic chemistry since 2001. She is also currently appointed as the deputy head of the Department of Chemistry being in charge of teaching matters.

Main interests: Dr. Mikkola has long worked on mechanisms and kinetics of hydrolytic reactions of RNA, related phosphodiesters and other biological phosphates, such as dinucleoside oligophosphates and sugar nucleotides.

 

 

 

 

Dr. Mikko Ora, Senior Lecturer

Mikko Ora has worked as Senior lecturer at Department of Chemistry, University of Turku since 2006.

Main interests: Prodrug strategies of nucleotides and biologically active phosphate esters as goal to develop the degradable lipophilic carriers, the protecting groups, which are used to improve the cellular membrane penetration. The kinetic studies of the prodrugs to obtain mechanistic information on the chemical hydrolysis and enzymatic cleavage of the protecting groups. Syntheses of structurally modified nucleoside analogues.

 

 

 

Dr. Heidi Korhonen, University Lecturer

Heidi Korhonen has worked as a University lecturer at the Department of Chemistry, University of Turku since autumn 2006. Currently she is working as an University lecturer.

Main interests: Mechanistic studies, including metal-ion catalyzed reactions, of RNA phosphodiester bond and other biologically active phosphate esters. Nucleoside phosphorylation. Enzyme-free, DNA-templated ligation reactions.

 

 

 

 

 

Dr. Ville Tähtinen, Postdoctoral researcher

Research interest: Development of high affinity triplex-forming probes for double helical nucleic acids, including aminoglycoside conjugates and chiral triplex forming PNAs, 19F NMR detection of triple helical RNA and DNA complexes.

 

 

 

 

 

Dr. Tharun Kumar Kotammagari

Tharun is working as a Postdoctoral Researcher of Turku Collegium of Science and Medicine. He received his Ph.D. in 2018 at CSIR-National Chemical Laboratory in Pune, India, and has a strong background in the synthesis of carbohydrate derivatives. After defending his thesis, Tharun completed a post-doctoral term at the University of Albany, U.S., and is now ready to start his second one with us. After all the trouble COVID has given us, we are excited to finally have him here! In the Bioorganic group, Tharun will expand his expertise from carbohydrates to modified nucleosides and nucleic acids, developing covalently mercurated hybridization probes for the detection and isolation of sulfur-containing tRNAs.

 

 

 

 

DOCTORAL CANDIDATES

 

M. Sc. Lange Yakubu Saleh

Research interest: Organomercury RNA cleaving agents

 

 

 

 

 

M. Sc. Madhuri Hande 

Research interests: Synthesis and properties of oligonucleotides incorporating organometallic  nucleobase surrogates, Metal mediated base pairing, in vivo-PET imaging of oligonucleotide conjugates

 

 

 

 

 

 

M. Sc. Asmo Aro-Heinilä

Research interest: Synthesis and properties of oligonucleotides incorporating organometallic  nucleobase surrogates, high affinity metal mediated 19F NMR-probes

 

 

 

 

 

M. Sc. Vijay Gulumkar 

Reserach interests: Synthesis of oligonucleotide carbohydrate conjugates, in vivo-PET imaging of of oligonucleotide conjugates, small DNA-based self-asembled constructs assisteed by reversible and irreversible covalent cross-linkages and their drug delivery applications

 

 

 

 

 

 

M. Sc. Antti Äärelä 

Research interests: Site-specific covalent conjugation of oligonucleotides with antibody-based fragments

 

 

 

 

 

 

 

M. Sc. Aapo Aho

Research interests: Hybridization-driven combinatorial libraries, DNA-templated ligation and oligomerization

 

 

 

 

 

  M. Sc. Dattatraya Ukale 

Research interest: Synthesis and properties of oligonucleotides incorporating organometallic  nucleobase surrogates, Metal mediated base pairing (in particular Hg-mediated systems), NMR-spectroscopy.

 

 

 

 

 

M. Sc. Tommi Österlund

Research interests: Nucleic acid templated chemistry and glycosylation in aqueous solutions.

 

 

 

 

 

 

 

M. Sc. Afari Mark

Research interests: Rational design of palladated oligonucleotides

 

 

 

 

 

 

 

 

 

M. Sc. Petja Rosenqvist   

Research interests: Chemical modification of rare C-nucleosides produced by soil bacteria, small molecular anti-cancer drugs, liquid phase oligonucleotide synthesis on soluble supports

 

 

 

 

 

 

M. Sc. Marika Karskela   Research interests: Synthesis of oligonucleotide ccarbohydrate conjugates

 

M. Sc. Vyacheslav Kungurtsev    Research interests: Large sacle liquid phase synthesis of oligonucleotides