Recent research activity is focused on new, enzyme-free, DNA-templated ligation reactions. These reactions produce backbone-modified DNA that may have potential in nucleic acid based diagnosis, drug discovery and study of biological systems.
1) Österlund T., Korhonen, H., Virta, P. DNA-Templated N(Me)-Alkoxyamine Glycosylation, Org. Lett. 2018, 20, 1496. https://pubs.acs.org/doi/10.1021/acs.orglett.8b00113